The cast of ER will reunite on “Stars In The House”, George Clooney, Noah Wyle, Julianna Margulies and Anthony Edwards to join

Seth Rudetsky and James Wesley announced today that the cast of “ER” will reunite on “Stars In The House” for a special Earth Day episode benefiting Waterkeeper Alliance, the fastest growing global non-profit focused solely on clean water.

Nearly 30 years after ER premiered, the beloved cast of the medical drama is reuniting!

On April 22, multiple stars of the long-running series will come together for a live, virtual reunion on the daily series Stars in the House, PEOPLE will exclusively reveal.

Also joining the virtual reunion: Laura Innes (who played Kerry Weaver), Alex Kingston (Elizabeth Corday), Goran Visnjic (Luka Kovac), Paul McCrane (Robert Romano), Ming-Na Wen (Jing-Mei Chen), Laura Cerón (Chuny Marquez), Yvette Freeman (Haleh Adams), Conni Marie Brazelton (Connie Oligario), and CCH Pounder (Angela Hicks).

Fans will be able to ask questions live and donate to Waterkeeper Alliance. And of course, there is a good chance for some live music!

What Reuben has to say on Reunion

“I am absolutely thrilled to be reuniting with my ‘ER’ family for a cause that is so close to my heart, and so grateful to Seth and James for allowing us to use their incredible platform to do so,” said Reuben.

“I’ve been involved with Waterkeeper Alliance for fifteen years, representing over 350 community-based Waterkeepers around the globe, and the work that they do is beyond comparison. We must continue to fight for clean water not just on Earth Day, but all year round!”

“I am absolutely thrilled to be reuniting with my ER family for a cause that is so close to my heart, and so grateful to Seth and James for allowing us to use their incredible platform to do so,” Reuben, 56, said in a statement.

“I’ve been involved with Waterkeeper Alliance for 15 years, representing over 350 community-based Waterkeepers around the globe, and the work that they do is beyond comparison,” she continued. “We must continue to fight for clean water not just on Earth Day, but all year round!”

The ER reunion episode will stream exclusively on People’s social platforms Facebook, Twitter, and YouTube, as well as on People TV’s Facebook and Twitter, and on the Stars In The House YouTube channel and StarsInTheHouse.com. Viewers will be able to ask questions live and donate to Waterkeeper Alliance and The Actors Fund.